Cell Stem Cell | PDO可预测局部晚期直肠癌的放化疗反应

Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

Cell Stem Cell. VOLUME 26, ISSUE 1, P17-26.E6, JANUARY 02, 2020

In Brief

Yao et al. generated a patient-derived organoid (PDO) biobank from patients with locally advanced rectal cancer (LARC) and reported that organoids had similar molecular profiles to those of the patient tumor and that PDOs can predict LARC patient chemoradiation responses, reinforcing their value as a companion diagnostic tool in LARC treatment.

 

Highlights

Living biobank with 80 tumor organoids was derived from treatment-naive CRC patients

Tumor organoids recapitulate histological and genetic features of original tumors

Interpatient variability in the PDO response to chemoradiation treatments

PDOs can predict locally advanced rectal cancer patient responses in the clinic

Yao 等人建立了一个局部晚期直肠癌 (LARC) 患者来源类器官 (PDO) 生物样本库，并在报告中指出类器官具有与患者肿瘤相似的分子特征，而且 PDO 能够预测 LARC 患者的放化疗反应，从而可增强其在 LARC 治疗中作为伴随诊断工具的价值。

• 该生物样本库包含 80 个肿瘤类器官并且均来自初治 CRC 患者

• 肿瘤类器官能够重现其原始肿瘤的组织学和遗传学特征

• PDO 对放化疗的反应存在患者间差异性

• PDO 能够预测临床上局部晚期直肠癌患者的治疗疗效

原文链接：https://doi.org/10.1016/j.stem.2019.10.010